Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

In the Research Topic "History of Chemoattractant Research" we will portray some of the key discoveries that helped to transform cell migration research into a global playing field within immunology (and beyond). Early progress had a profound effect on both, academia and industry. Today, numerous academic laboratories are fully engaged in compiling a detailed road map describing the highly complex network of immune and tissue cells that respond to chemoattractants. Industrial research, on the other hand, centers on drugs that interfere with immune cell traffic in inflammatory diseases and cancer. The following series of “short stories” provide personal accounts on key discoveries. The individual molecular discoveries enabled numerous research laboratories worldwide to unravel their significance in steady-state or pathological immune processes. Although ground-breaking in their own right, it is therefore worth emphasizing that rapid progress in chemoattractant research was made possible by many other laboratories who were not directly involved in the original discovery process. Therefore, the authors of this mini-series are discussing their findings in the context of time, place and subsequent progress enabled by their discoveries. It is hoped that a wide readership will find these accounts entertaining as well as educational although those who wish to gain a more detailed knowledge are referred to the many outstanding reviews on chemokines and other chemoattractants.

Homing --- chemokine --- tumour --- cell migration --- Inflammation --- Chemotaxis --- Immunity --- immune surveillance

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The aim of the issue is to describe and explain the importance of the chemokine system in hematology. As described in the introduction the chemokine system is probably important for many aspects of normal as well as malignant hematopoiesis. A major focus is the development and treatment of hematologic malignancies, including the immunobiology of stem cell transplantation.” The present reviews illustrate that chemokines can be involved in leukemogenesis. The chemokine system is also important both for the crosstalk between malignant cells and their neighbouring nonmalignant stromal cells (including endothelial cells) as well as for immunoregulation in patients treated with allogeneic stem cell transplantation. Thus, chemokines are important both for the pathogenesis and treatment of hematological diseases.

Blood -- Diseases -- Immunological aspects. --- Blood -- Diseases. --- Chemokines. --- Hematology, Experimental. --- Hematology. --- Chemokines --- Hematology, Experimental --- Blood --- Antigens, CD --- Cell Transplantation --- Cytokines --- Inflammation Mediators --- Chemotaxis --- Chemotactic Factors --- Biological Science Disciplines --- Receptors, G-Protein-Coupled --- Receptors, Cytokine --- Leukemia, Myeloid --- Immune System Diseases --- Chemotaxis, Leukocyte --- Stem Cell Transplantation --- Receptors, Chemokine --- Graft vs Host Disease --- Leukemia, Myeloid, Acute --- Physiology --- Leukemia --- Natural Science Disciplines --- Biological Factors --- Intercellular Signaling Peptides and Proteins --- Antigens, Differentiation --- Diseases --- Transplantation --- Receptors, Immunologic --- Cell Movement --- Receptors, Cell Surface --- Biological Markers --- Peptides --- Neoplasms by Histologic Type --- Proteins --- Disciplines and Occupations --- Chemicals and Drugs --- Surgical Procedures, Operative --- Antigens, Surface --- Membrane Proteins --- Cell Physiological Processes --- Amino Acids, Peptides, and Proteins --- Neoplasms --- Antigens --- Cell Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Phenomena and Processes --- Medicine --- Biology --- Oncology --- Microbiology & Immunology --- Health & Biological Sciences --- Immunological aspects. --- Chemotactic cytokines --- Inflammatory peptides --- Intercrines --- Experimental hematology --- Haematology --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Internal medicine --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Inflammation --- Medicine, Experimental --- Physiology, Experimental --- Body fluids --- Fear of blood --- Mediators --- Oncology. --- Tumors

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This open access book deals with a rich variety of taxis-type cross-diffusive equations. Particularly, it intends to show the key role played by quasi-energy inequality in the derivation of some necessary a priori estimates. This book addresses applied mathematics and all researchers interested in mathematical development of reaction-diffusion theory and its application and can be a basis for a graduate course in applied mathematics.

Boundary value problems. --- Chemotaxis --- Navier-Stokes equations. --- Mathematical models. --- Equations, Navier-Stokes --- Differential equations, Partial --- Fluid dynamics --- Viscous flow --- Chemiotaxis --- Chemotropism --- Biochemistry --- Growth --- Taxes (Biology) --- Boundary conditions (Differential equations) --- Differential equations --- Functions of complex variables --- Mathematical physics --- Initial value problems --- Problemes de contorn --- Quimiotaxi --- Models matemàtics --- Equacions de Navier-Stokes --- Navier-Stokes (Equacions) --- Dinàmica de fluids --- Equacions en derivades parcials --- Models (Matemàtica) --- Models experimentals --- Models teòrics --- Mètodes de simulació --- Anàlisi de sistemes --- Mètode de Montecarlo --- Modelització multiescala --- Models economètrics --- Models lineals (Estadística) --- Models multinivell (Estadística) --- Models no lineals (Estadística) --- Programació (Ordinadors) --- Simulació per ordinador --- Teoria de màquines --- Models biològics --- Bioquímica --- Creixement --- Problemes de valor límit --- Equacions diferencials --- Física matemàtica --- Funcions de variables complexes --- Dispersió (Matemàtica) --- Equacions de Von Kármán --- Problema de Dirichlet --- Problema de Neumann --- Problemes de Riemann-Hilbert --- Problemes de valor inicial --- Reaction-Diffusion --- Haptotaxis --- Navier-Stokes --- Cancer invasion --- Coral fertilization --- Sensity-suppressed motility --- Oncolytic virotherapy --- Foraging scrounging interplay

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Nowadays, assisted reproductive technologies (ARTs) have a pivotal role not only in achieving fertilization in subfertile animals, but they are also involved in the management of the herd, decreasing disease spread and even allowing offspring sex selection. Nonetheless, there are differences between species or even within species that have led researchers worldwide to focus on those differences in order to bypass these specific difficulties. This Special Issue, titled “The Era of Assisted Reproductive Technologies Tailored to the Specific Necessities of Species, Industry and Case Reports” and published in Animals, is composed of 12 original manuscripts and three reviews that offer an overview of current and future ARTs used to improve reproductive outcomes, mainly focused on farm animals, such as horse, pig, bovine, rabbit and ovine species. Thus, the Special Issue covers information from the classical point of view, including comparative studies of different semen extenders, to the most advanced technologies of sperm selection by thermotaxis or chemoattractants, as well as the improvement of sperm features by red light irradiation. The female and embryo contributions to ART outcomes are also covered, for instance, with a study that improves our knowledge by the metabolomic description of follicular fluid composition or the description of better culture conditions of oocytes. In brief, this Special Issue provides a balanced overview of emerging techniques and technologies used to preserve, improve, rescue or even create fertility for domestic farm animals with high economic impact.

IVM --- oocytes --- equine --- metabolomic --- embryo transfer --- reproductive fluids --- pregnancy --- vitrification --- calving --- selection programme --- embryo vitrification --- Gompertz growth curve --- biobanking --- reproductive performance --- stallion sperm --- capacitation --- penicillamine --- thermotaxis --- selection --- BMP15 --- ram --- semen --- semen freezing --- semen extender --- stallions --- semen quality --- fertilizing ability --- Tris --- boar spermatozoa --- perfluorinated compounds --- PFHxS --- PFOS --- spermatozoa toxicology --- glucocorticoid receptor --- gene expression --- RT-qPCR --- seminal plasma --- female genital tract --- rabbit --- spermatozoa --- oocyte --- in vitro fertilization --- extracellular vesicles --- assisted reproductive technologies --- embryo --- oocyte competence --- livestock production --- assisted reproductive technology --- embryo development --- micromanipulation --- in vitro production --- nanoparticles --- liposomes --- exosomes --- cryopreservation --- sheep --- ovary storage --- transport --- in vitro embryo production --- sperm selection --- chemotaxis --- IVF --- IVC --- porcine --- cryopreserved sperm --- sperm–oviduct interaction --- ARTs --- equines --- horse --- sperm --- red light irradiation --- extender --- straw

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Pursuing the questions of how we learn and how memory is made, Edward Kosower introduces a novel and rich approach to connecting molecular properties with the biological properties that enable us to write and read, to create culture and ethics, and to think. Here he examines what happens within a single cell in reaction to external stimuli, and shows the parallels between single cell and multicellular responses. To address the problem of "learning," Kosower explains the molecular mechanisms of responses to input from taste, olfactory, and visual receptors. He then shows how these and other processes serve as the basis for memory. This study covers such signals for the molecular process of learning as pheromones (the molecular signals mediating behavior), light (activates the G-protein receptor, rhodopsin), and acetylcholine (opens the nicotinic acetylcholine receptor). Kosower's discussion of the structure and function of these complex molecules has direct implications for such areas as molecular neurobiology, bioorganic chemistry, and drug design, in elucidating approaches to the structure of drug targets.Originally published in 1991.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Molecular neurobiology. --- Cellular signal transduction. --- Molecular recognition. --- Action potential. --- Activation. --- Amino acid. --- Antibody. --- Bilayer. --- Binding protein. --- Biological Assay. --- Biological membrane. --- Biological neural network. --- Biomolecular structure. --- Biosynthesis. --- Catalysis. --- Caudate nucleus. --- Cell surface receptor. --- Chemical change. --- Chemical modification. --- Chemical synapse. --- Chemoreceptor. --- Chemotaxis. --- Chromatin. --- Chromophore. --- Conformational change. --- Creatine kinase. --- Demethylation. --- Electron transport chain. --- Enzyme. --- GABA receptor. --- GABAA receptor. --- Ganglion cell. --- Gel electrophoresis. --- Gene product. --- Globulin. --- Glycine receptor. --- Golgi apparatus. --- Golgi cell. --- Ion channel. --- LTP induction. --- Libration (molecule). --- Ligand (biochemistry). --- Lysine. --- Lysozyme. --- Mechanism of action. --- Mechanoreceptor. --- Membrane potential. --- Methylation. --- Methyltransferase. --- Microvillus. --- Molecular configuration. --- Molecular electronic transition. --- Molecular graphics. --- Molecular sieve. --- Molecule. --- Motor neuron. --- Muscarinic acetylcholine receptor. --- Mutagen. --- Neurofilament. --- Neuroglia. --- Neurokinin A. --- Neuron. --- Neuropeptide. --- Neurotransmitter. --- Nicotinic acetylcholine receptor. --- Olfactory receptor neuron. --- Organism. --- Peptide. --- Permease. --- Pheromone binding protein. --- Pheromone. --- Phosphodiesterase. --- Phosphorylation. --- Physical organic chemistry. --- Plasma protein binding. --- Post-translational modification. --- Protein methylation. --- Protein phosphorylation. --- Protein primary structure. --- Protein structure. --- Protein synthesis inhibitor. --- Protein. --- Proteolysis. --- RNA interference. --- Receptor (biochemistry). --- Receptor modulator. --- Receptors, Neurotransmitter. --- Regulation of gene expression. --- Retina. --- Rhodopsin kinase. --- Rhodopsin. --- Sensory neuron. --- Side chain. --- Signal processing. --- Signal transduction. --- Sodium channel. --- Stimulus (physiology). --- Synapsin I. --- Synapsis. --- Synaptosome. --- Teratology. --- Transducin. --- Transposable element.